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Welcome to the Esther web-service.

Esther is an interface to a suite of tools for discrete simulation a reverse-engineering of gene regulatory and signal transduction networks. For modelling we employ the framework of asynchronous boolean or multi-valued (commonly referred to as Thomas or Qualitative) networks. Currently Esther allows for conduction of the following tasks:

• Creating a regulation or signal transduction model.
• Partial / full specification of kinetic parameters.
• Automated parameter filtering by edge constraints and/or LTL formulae.
• Comparison of parametrised models.
• Manual parameter filtering.
• Visualisation of the dynamics.
• File storage and management, file transfer.

For a more thorough description of the platform please refer to the Guide page. The theoretical background of the computation is described in this pdf.

To access the tool-set and also obtain a server-side storage and computational capacity, please register. An e-mail with an activation link for your account will be sent to you within 24 hours.

News:

Esther is being developed in collaboration of members of the Systems Biology Laboratory of Masaryk University and the Discrete Biomathematics group of Freie Universität of Berlin.

The source code is distributed under GNU general public license v3 and is available on GitHub.